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2014


Auffarth K, Arlt H, Lachmann J, Cabrera M, Ungermann C (2014) Tracking of the dynamic localization of Rab-specific HOPS subunits reveals their distinct interaction with Ypt7 and vacuoles. Cell Log, 4, e29191 [PDF]


Kümmel D, Ungermann C (2014) Principles of membrane tethering and fusion in endosome and lysosme biogenesis. Curr Opin Cell Biol, 29, 61-66. [PDF]


Hönscher C, Mari M, Auffarth K, Bohnert M, Griffith J, Geerts W, van der Laan M, Cabrera M, Reggiori F, Ungermann C (2014) Cellular metabolism regulates contact sites between vacuoles and mitochondria. Dev Cell, 30, 86-94. [PDF][Dev. Cell]


Lawrence G, Brown CC, Flood BA, Karunakaran S, Cabrera M, Nordmann M, Ungermann C, and Fratti RA (2014) Dynamic association of the PI3P-interacting Mon1-Ccz1 GEF with vacuoles is controlled through ist phosphorylation by the type-1 casein kinase Yck3. Mol Biol Cell, 25, 1608-19. [PDF][MBC]


Gautreau A, Oguievetskaia K, Ungermann C (2014) Function and regulation of the endosomal fusion and fission machineries. Cold Spring Harb Perspect Biol 6, pii: a016832


Cabrera M, Nordmann M, Perz A, Schmedt D, Gerondopoulos A, Barr F, Piehler J, Engelbrecht-Vandré S, Ungermann C (2014) The Mon1-Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin-fold-Rab interface and association with PI3P-positive membranes. J Cell Sci 127, 1043-51. [PDF][JCS]


Hönscher C, Ungermann C (2014) A close-up view of membrane contact sites between the endoplasmic reticulum and the endolysosomal system: From yeast to man. Crit Rev Biochem Mol Biol, in press [PDF][CRBNB]


Numrich J, Ungermann C (2014) Endocytic Rabs in membrane trafficking and signaling. Biol Chem 395, 327-33. [PDF][BC]


2013


Guo Z, Johnston W, Kovtun O, Mureev S, Bröcker C, Ungermann C, Alexandrov K (2013) Subunit organization of in vitro reconstituted HOPS and CORVET multisubunit membrane tethering complexes. PLoS One 8, e81534 [PDF][PLOSOne]


Cabrera M, Arlt H, Epp N, Lachmann J, Griffith J, Perz A, Reggiori F, and Ungermann C (2013) Functional separation of endosomal fusion factors and the CORVET tethering complex in endosomal biogenesis. J Biol Chem, 288, 5166-75. [PDF][JBC]


Rieter E, Vinke F, Bakula D, Cebollero E, Ungermann C, Projkas-Cezanne T, and Reggiori F (2013) Atg18 function in autophagy is regulated by specific sites within its beta-propeller. J Cell Sci, 126, 593-604. [PDF][JCS]


Cabrera M, and Ungermann C (2013). Guanine nucleotide exchange factors (GEFs) have a critical but not exclusive role in organelle localization of Rab GTPases. J Biol Chem, 288, 28704–28712. [PDF][JBC]


Guo Z, Johnston W, Kovtun O, Mureev S, Bröcker C, Ungermann C, and Alexandrov K (2013). Subunit Organisation of In Vitro Reconstituted HOPS and CORVET Multisubunit Membrane Tethering Complexes. PLoS ONE, 8, e81534. [PDF][PLOSOne]


Epp N, and Ungermann C (2013). The N-Terminal Domains of Vps3 and Vps8 Are Critical for Localization and Function of the CORVET Tethering Complex on Endosomes. PLoS ONE, 8, e67307. [PDF][PLOSOne]


Balderhaar, H.J. and Ungermann, C. (2013) CORVET and HOPS tethering complexes - coordinators of endosome and lysosome fusion. J Cell Sci 126, 1307-1316. [PDF][JCS]


John Peter, A.T., Lachmann, J., Rana, M., Bunge, M., Cabrera, M. and Ungermann, C. (2013) The BLOC-1 complex promotes endosomal maturation by recruiting the Rab5 GTPase-activating protein Msb3. J Cell Biol 201, 97-111. [PDF][JCB]


Balderhaar, H.J., Lachmann, J., Yavavli, E., Broecker, C., Luerick, A. and Ungermann, C. (2013) The CORVET complex promotes tethering and fusion of Rab5/Vps21-positive membranes. PNAS 110, 3823-3828. [PDF][PNAS]


2012


Cabrera, M., Arlt, H., Epp, N., Lachmann, L., Griffith, J., Perz, A., Reggiori, F. and Ungermann, C. (2012) Functional seperation of endosomal fusion factors and the CORVET tethering complex in endosome biogenesis. J Biol Chem, 288, 5166-5175. [PDF][JBC]


Reggiori, F., and Ungermann C. (2012) A dimer to bridge early autophagosomal membranes. Cell 151, 1403-5. [PDF][Cell]


Holthuis, J.C. and Ungermann, C. (2012) Cellular microcompartments constitute general sub-organellar functional units in cells. Biol Chem, in press [PDF][BC]


Nordmann, M., Ungermann, C. and Cabrera, M. (2012) Role of Rab7/Ypt7 in Organizing Membrane Trafficking at the Late Edosome. Rab GTPases and Membrane Trafficking, 10, 132-143. [PDF][RGMT]


Cabrera, A., Herrmann, S., Warszta, D., Santos, L.M., John Peter, A.T., Kono, M., Debrouver, S., Jacobs, T., Spielmann, T., Ungermann, C., Soldati-Favre, D. and Gilberger, T.W. (2012) Dissection of minimal sequence requirements for rhoptry membrane targeting in malaria parasite. Traffic, 10, 1335-50. [PDF][TRAFFIC]


Lachmann, J., Barr, F.A. and Ungermann, C. (2012) The Msb3 GAP controls the activity of the Rab GTPases Vps21 and Ypt7 at endosomes and vacuoles. Mol Biol Cell, in press. [PDF][MBC]


Bonfils, G., Jaquenoud, M., Bontron, S., Ostrowicz, C., Ungermann, C. and De Virgilio, C. (2012) Leucyl-tRNA synthetase controls TORC1 via the EGO complex. Mol Cell, 13, 2516-26. [PDF][MC]


Bröcker, C., Kuhlee, A., Gatsogiannis, C., Kleine Balderhaar, H.J., Hönscher C., Engelbrecht-Vandré, S., Ungermann, C. and Raunser, S. (2012) Molecular architecture of the multisubunit homotypic fusion and vacuole protein sorting (HOPS) tethering complex. PNAS 109, 1991-6. [PDF][PNAS]


2011


Kama, R., Kanneganti, V., Ungermann, C. and Gerst, J.E. (2011) The yeast Batten disease orthologue Btn1 controls endosome-Golgi retrograde transport via SNARE assembly. J Cell Biol., 195, 203-15. [PDF][JCB]


Arlt, H., Perz, A. and Ungermann, C. (2011) An overexpression screen in Saccharomyces cerevisiae identifies novel genes that affect endocytic protein trafficking. Traffic 12, 1592-1603. [PDF][TRAFFIC]


Lachmann, J., Engelbrecht-Vandré and Ungermann, C. (2011) Rab GTPases and tethering in the yeast endocytic pathway. Small GTPases, 3,182-186. [PDF][SG]


Epp, N., Rethmeier, R., Krämer, L. and Ungermann, C. (2011) Membrane dynamics and fusion at late endosomes and vacuoles - Rab regulation, multisubunit tethering complexes and SNAREs. EJCB, 90:779-785. [PDF][EJCB]


Krämer, L. and Ungermann, C. (2011) HOPS drives vacuole fusion by binding the vacuole SNARE complex and the Vam7 PX domain via two distinct sites. Mol Biol Cell, 22, 2601-2611. [PDF][MBC]


Meringer, C.T., Rethmeier, R., Auffarth, K., Wilson, J., Perz, A., Barlowe, C. Schmitt, H.D., and Ungermann, C. (2011) The Dsl1 tethering complex is a resident ER complex, which interacts with five SNAREs - implications for fusion and fusion regulation. J. Biol Chem., 28, 25039-46. [PDF][JBC]


2010


Cabrera, M., Langemeyer, L., Muri, M., Rethmeier, R., Orban, I., Perz, A., Bröcker, C., Griffith, J., Klose, D., Steinhoff, H.J., Reggiori, F., Engelbrecht-Vandré and Ungermann, C. (2010) Phosphorylation of a membrane curvature-sensing motif switches function of the HOPS subunit Vps41 in membrane tethering. J. Cell. Biol, 191, 845-59. [PDF][JCB]


Kleine Balderhaar, H.J., Arlt, H., Ostrowicz, C., Bröcker, C., Sündermann, F., Brandt, R., Babst, M., and Ungermann, C. (2010) The Rab GTPase Ypt7 is linked to retromer-mediated receptor recycling and fusion at the late endosome . J. Cell Sci. , 123, 4085-94. [PDF][JCS]


Bröcker, C., Engelbrecht-Vandré, S., and Ungermann, C. (2010) Multisubunit tethering complexes and their role in membrane fusion. Curr. Biol., 20, 943-52. [PDF][Curr. Biol.]


Nordmann, M., Cabrera, M., Perz, A., Bröcker, C., Ostrowicz, C., Engelbrecht-Vandré, S., and Ungermann, C. (2010) The Mon1-Ccz1 complex is the GEF of the Rab7-homolog Ypt7. Curr. Biol., 20, 1654-9. [PDF][Curr. Biol.]


Ostrowicz, C., Bröcker, C., Ahnert, F., Nordmann, M., Lachmann, J., Peplowska, K., Perz, A., Auffarth, K., Engelbrecht-Vandré, S., and  Ungermann, C. (2010) Defined subunit arrangements and Rab interactions are required for functionality of the HOPS tethering. Traffic, 11, 1334-46. [PDF][Traffic]


Cabrera, M., and Ungermann, C. (2010) Guiding endosomal maturation. Cell, 141, 404-6. [PDF][Cell]


2009


Markgraf, D.M., Ahnert, F., Arlt, H., Marie, M., Peplowska, K., Epp, N., Griffith, J., Reggiori, F., and Ungermann, C. (2009) The CORVET subunit Vps8 cooperates with the Rab5. homolog Vps21 to induce clustering of late endosomal compartments. Mol. Biol. Cell, 20, 5276-89. [PDF][MBC]


Hou, H., John Peter, A.T., Meiringer, C., Subramanian, K., and Ungermann, C. (2009) Analysis of DHHC acyltransferases implies overlapping substrate specificity and a two-step reaction mechanism. Traffic, 10, 1061-73. [PDF][Traffic]


Cabrera, M., Ostrowicz, C., Muri, M. Reggiori, F., and Ungermann, C. (2009) Vps41 phosphorylation and the Rab Ypt7 control the targeting of the HOPS complex to endosome-vacuole fusion sites. Mol. Biol. Cell, 20, 1937-48. [PDF][MBC]



2008


Cabrera, M., and Ungermann, C. (2008) Purification and in vitro analysis of yeast vacuoles. Methods. Enzymolog 481, 177-96. [PDF][MIE]


Peplowska, K., Cabrera, M., and Ungermann, C. (2008) UVRAG reveals its second nature. Nat. Cell Biol. 10, 759-61. [PDF][NCB]


Meiringer, C.M., Auffarth, K., Hou, H., and Ungermann, C. (2008) Depalmitoylation of the SNARE Ykt6 prevents its entry into the multivesicular body pathway. Traffic 9, 1510-21. [PDF][Traffic]


Takeda, K., Cabrera, M., Rohde, J., Bausch, D., Jensen, O.N., and Ungermann, C. (2008) The vacuolar V1/Vo-ATPase is involved in the release of the HOPS subunit Vps41 from vacuoles, vacuole fragmentation and fusion. FEBS Lett 582, 1558-1563 [PDF][FEBS]


Ostrowicz, C.F., Meiringer, C.M., and Ungermann, C. (2008) Yeast vacuole fusion: A model system for eukaryotic endomembrane dynamics. Autophagy 4, 1-15 [PDF][Autophagy]


2007


Peplowska, C., Markgraf, D.M., Ostrowicz, C.F., Bange, G., and Ungermann, C. (2007) The CORVET tethering complex interacts with the yeast Rab5 homolog Vps21 and is involved in endo-lysosomal biogenesis. Dev. Cell 12, 739-750 [PDF][Dev. Cell]


Langosch, D., Hoffmann, M., and Ungermann, C. (2007) The role of transmembrane domains in membrane fusion. Cell Mol. Life Sci. 64, 850-864 [PDF][Cell Mol Life Sci.]


Markgraf, D.M., Peplowska, K., and Ungermann, C. (2007) Rab cascades and tethering factors in the endomembrane system. FEBS letters 581, 2125-2130 [PDF][FEBS]


2006


Hofmann,M., Peplowska, K., Rohde, J., Poschner, B.C., Ungermann, C., and Langosch, D. (2006) Self-interaction of a SNARE transmembrane domain promotes hemifusion-to-fusion transition. J. Mol. Biol. 346, 1048-1060 [PDF][JMB]


Meiringer, C., and Ungermann, C. (2006) Probing protein palmitoylation at yeast vacuoles. Methods 40, 171-176.[PDF][Methods]


Roy, R., Peplowska, K., Rohde, J., Ungermann, C., and Langosch, D. (2006) Role of the Vam3p transmembrane segment in homodimerization and SNARE complex formation. Biochemistry 45, 7654-7660 [PDF][Biochemistry]


Subramanian, K., Dietrich, L.E.P., Hou, H., LaGrassa, C., Meiringer, C., and Ungermann, C. (2006) Palmitoylation determines the function of Vac8 at the yeast vacuole. J. Cell Sci. 119, 2477-2485 [PDF][JCS]


2005


Hou, H., Subramanian, K., LaGrassa, T.J., Markgraf, D., Dietrich, L.E.P., Decker, N., and Ungermann, C. (2005) The DHHC protein Pfa3 affects vacuole-associated palmitoylation of the fusion factor Vac8. PNAS 102, 17366-17371[PDF][PNAS]


Ungermann, C., and Langosch, D. (2005) Functions of SNAREs in intracellular membrane fusion and lipid bilayer mixing. J. Cell Sci. 118, 3819-3828. [PDF][JCS]


Dietrich, L.E.P., LaGrassa, T.J., Rohde, J., Cristodero, M., Meiringer, C., and Ungermann, C. (2005) ATP-independent control of Vac8 palmitoylation by a SNARE sub-complex on yeast vacuoles. J. Biol. Chem. 280, 15348-15355 [PDF][JBC]


Dietrich, L.E.P., Peplowska, K., LaGrassa, T.J., Hou, H., Rohde, J., and Ungermann, C. (2005) The SNARE Ykt6 gets released from yeast vacuoles during an early stage of fusion. EMBO Rep.6, 245-250 [PDF][EMBO]


Peplowska, K., and Ungermann, C. (2005) Expanding dynamin: from fission to fusion. Nat. Cell Biol. 7, 103-104. [PDF][NCB]


LaGrassa, T.J., and Ungermann, C. (2005) The vacuolar kinase Yck3 maintains organelle fragmentation by regulating the HOPS tethering complex. J. Cell Biol. 168, 401-14. [PDF][JCB]


2004


Rossi, V., Banfield, D.K., Vacca, M., Dietrich, L.E.P, Ungermann, C., D'Esposito, M., Galli, T., and Filippini, F. (2004) Longins and their longin domains: regulated SNAREs and multifunctional SNARE regulators. Trends Biochem. Sci. 29, 682-8. [PDF][TIBS]


Dietrich, L.E.P., and Ungermann, C. (2004) On the mechanism of protein palmitoylation. EMBO Rep. 5, 1053-57 [PDF][EMBO Rep.]


Faergeman, N.J., Feddersen, S., Christiansen, J.K., Larsen, M.K., Schneiter, R., Ungermann, C., Mutenda, K., Roepstorff, P., and Knudsen, J. (2004) Acyl-CoA binding protein, Acb1p, is required for normal vacuole function and ceramide synthesis in Saccharomyces cerevisiae. Biochem. J. 380, 907-18. [PDF][Biochem.J.]


Dietrich, L.E.P., Gurezka, R., Veit, M., and Ungermann, C. (2004) The SNARE Ykt6 mediates protein palmitoylation during an early stage of vacuole fusion. EMBO J. 23, 45-53. [PDF][EMBO]


2003


Rohde, J., Dietrich, L.S.P., Langosch, D., and Ungermann, C. (2003) The transmembrane domain of Vam3 affects the composition of cis- and trans- SNARE complexes to promote homotypic vacuole fusion. J. Biol.Chem. 157, 79-89. [PDF][JBC]


Veit, M., Dietrich, L.E.P., and Ungermann, C. (2003) Biochemical characterization of the vacuolar palmitoyl acyltransferase. FEBS letters, 540, 101-105. [PDF][FEBS]


Dietrich, L.E.P., Boeddinghaus, C., LaGrassa, T.J., and Ungermann, C. (2003) Control of eukaryotic membrane fusion by N-terminal domains of SNARE proteins. BBA reviews 1643, 111-119. [PDF][BBA]


2002


Boeddinghaus, C., Merz, A.J., Laage, R., and Ungermann, C. (2002). A cycle of Vam7p release from and PtdIns-3-P-dependent rebinding to the yeast vacuole is required for homotypic vacuole fusion. J. Cell Biol. 157, 79-90.[PDF][JCB]


2001


Laage, R.,and Ungermann, C. (2001) The N-terminal domain of the t-SNARE Vam3p coordinates priming and docking in yeast vacuole fusion. Mol. Biol. Cell.,12, 3375-3385.[PDF][MBC]


Veit, M., Laage, R., Dietrich, L., Wang, L., and Ungermann, C. (2001) Vac8p release from the SNARE complex and its palmitoylation are coupled and essential for vacuole fusion. EMBO J. 20, 3145-55. [PDF][EMBO]


Takita Y, Engstrom L, Ungermann C, Cunningham KW. (2001) Inhibition of the Ca(2+)-ATPase Pmc1p by the v-SNARE protein Nyv1p. J. Biol. Chem. 276, 6200-6. [PDF][JBC]


2000 and before


Ungermann, C., Price, A., and Wickner, W. (2000) A new role for a SNARE protein as a regulator of the Ypt/Rab-dependent stage of docking. PNAS 97, 8889-8891. [PDF][PNAS]


Wang L, Ungermann C, Wickner W. (2000) The docking of primed vacuoles can be reversibly arrested by excess Sec17p (alpha-SNAP). J. Biol. Chem. 275, 22862-7. [PDF][JBC]


Price A, Seals D, Wickner W, Ungermann C. (2000) The docking stage of yeast vacuole fusion requires the transfer of proteins from a cis-SNARE complex to a Rab/Ypt protein. J. Cell Biol. 148, 1231-8. [PDF][JCB]


Price A, Wickner W, Ungermann C. (2000) Proteins needed for vesicle budding from the Golgi complex are also required for the docking step of homotypic vacuole fusion. J. Cell Biol. 148, 1223-30. [PDF][JCB]


Ungermann C, Wickner W, Xu Z. (1999) Vacuole acidification is required for trans-SNARE pairing, LMA1 release, and homotypic fusion. PNAS 96, 11194-9. [PDF][PNAS]


Ungermann C, von Mollard GF, Jensen ON, Margolis N, Stevens TH, Wickner W.  (1999) Three v-SNAREs and two t-SNAREs, present in a pentameric cis-SNARE complex on isolated vacuoles, are essential for homotypic fusion. J. Cell Biol. 145; 1435-42. [PDF][JCB]


Ungermann, C., Sato, K., and Wickner, W. (1998) Defining the roles of trans SNARE pairs. Nature 396, 543-548. [PDF][Nature]


Ungermann, C., and Wickner, W. (1998) Vam7p, a vacuolar SNAP-25 homolog, is required for SNARE complex integrity and vacuole docking and fusion. EMBO J. 17, 3269-3276. [PDF][EMBO]


Ungermann, C., Nichols, B.N., Pelham, H.R.B., and Wickner, W. (1998). A vacuolar v-t-SNARE complex, the predominant form in vivo and on isolated organelles, is disassembled and activated for docking and fusion. J.Cell.Biol., 140, 61-69. [PDF][JCB]


Gaume B, Klaus C, Ungermann C, Guiard B, Neupert W, Brunner, M. (1998) Unfolding of preproteins upon import into mitochondria. EMBO J., 17, 6497-6507. [Abstract]


Nichols, B.N., Ungermann, C., Pelham, H.R.B., Wickner, W., and Haas, A. (1997). Homotypic vacuolar fusion mediated by v-and t-SNAREs. Nature, 387, 199-202. [Abstract]


Gieffers, C., Korioth, F.,  Heimann, P., Ungermann, C., and Frey, J. (1997) . Mitofilin is a transmembrane protein of the inner mitochondrial membrane expressed as two isoforms. Exp.Cell Res., 232, 395-9. [Abstract]


Wheeler, L.J., Ray, N.B. , Ungermann, C., Hendricks S.P., Bernard M.A., Hanson E.A., and Mathews, C.K. (1996). T4 Phage Gene 32 Protein as a Candidate Organizing Factor for the dNTP Synthetase Complex. J. Biol. Chem., 271, 11156-11162. [Abstract]


Ungermann, C., Guiard, B., Neupert, W., and Cyr, D.M. (1996) The DY and Hsp70/MIM44 dependent Reaction Cycle in Driving Early Steps of Protein Translocation into Mitochondria. EMBO J. 15, 735-744. [Abstract]


Ungermann, C., Neupert, W., and Cyr, D.M. (1995). Regulation of Protein Transport through Mitochondrial Membranes. Journal of NIH Research 6, 7, 60.


Cyr, D.M.., Ungermann, C., and Neupert, W. (1995). Analysis of Mitochondrial Protein Import with Translocation Intermediates. Methods Enzymol, 260, 241-252.


Ungermann, C., Neupert, W., and Cyr, D.M. (1994). The Role of Hsp70 in Conferring Unidirectionality on Protein Translocation into Mitochondria. Science 266, 1250-1255. [PDF][Science]


Mathews, C.K., Wheeler, L.J., Ungermann, C., Young, J.P., and Ray, N.B. (1993). Enzyme Interactions Involving T4-phage Coded Thymidylate Synthase and Deoxyhydroxymethylase. Adv. Med. Exp. Biol. 338, 563-570. [Abstract]

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