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a) Original publications


Edvardson S, Gerhard F, Jalas C, Lachmann J, Golan D, Rivas M , Shaag A, Ungermann C*, Orly E* (2015) Hypomyelination and developmental delay associated with VPS11 mutation in Ashkenazi-Jewish patients. J Med Gen, in press (*co-corresponding)

Rana M, Lachmann J, Ungermann C (2015) Identification of a Rab GAP cascade that controls recycling of the Rab5 GTPase Vps21 from the vacuole. Mol Biol Cell 26, 2535-49.

Numrich J, Péli-Gulli MP, Arlt H, Sardu A, Griffith J, Levine T, Engelbrecht-Vandré S, Reggiori F, DeVirgilio C, Ungermann C (2015) The I-BAR protein Ivy1 is an effector of the Rab7 GTPase Ypt7 involved in vacuole membrane homeostasis. J Cell Sci 128, 2278-92.

Lürick A, Kuhlee A, Bröcker C, Raunser S, Ungermann C (2015) The Habc domain of the SNARE Vam3 interacts with the HOPS tethering complex to facilitate vacuole fusion. J Biol Chem 9, 5405-5413.

Arlt H, Reggiori F, Ungermann C (2015) The retromer complex cooperates with the dynamic Vps1 in the retrieval of transmembrane proteins from the vacuole. J Cell Sci 128, 645-655.

Arlt H, Auffarth K, Kurre R, Lisse D, Piehler J, Ungermann C (2015) Spatio-temporal dynamics of membrane remodeling and fusion proteins during endocytic transport. Mol Biol Cell 26, 1357-1370.

Wetzel J, Herrmann S, Swapna LS, Prusty D, Peter AT, Kono M, Saini S, Nellimarla S, Wong TW, Wilcke L, Ramsay O, Cabrera A, Biller L, Heincke D, Mossman K, Spielmann T, Ungermann C, Parkinson J, Gilberger TW (2015) The role of palmitoylation for protein recruitment to the inner membrane complex of the malaria parasite. J Biol Chem 290, 1712-1728.


Behrmann H, Lürick A, Kuhlee A, Balderhaar HK, Bröcker C, Kümmel D, Engelbrecht-Vandré S, Gohlke U, Raunser S, Heinemann U*, Ungermann C* (2014) Structural identification of the Vps18 b-propeller reveals a critical role in the HOPS complex stability and function. J Biol Chem 289, 33503-33512. (*co-corresponding)

Auffarth K, Arlt H, Lachmann J, Cabrera M, Ungermann C (2014) Tracking of the dynamic localization of the Rab-specific HOPS subunits reveal their distinct interaction with Ypt7 and vacuoles. Cell Logist 4, e29191.

Hönscher C, Mari M, Auffarth K, Bohnert M, Griffith J, Geerts W, van der Laan M, Cabrera M, Reggiori F, Ungermann C  (2014) Cellular metabolism regulates contact sites between vacuoles and mitochondria. Dev Cell 30, 86-94

Lawrence G, Brown CC, Flood BA, Karunakaran S, Cabrera M, Nordmann M, Ungermann C, Fratti RA (2014) Dynamic association of the PI3P-interacting Mon1-Ccz1 GEF with vacuoles is controlled through its phosphorylation by the type-1 casein kinase Yck3. Mol Biol Cell 25, 1608-1619.

Cabrera M, Nordmann M, Perz A, Schmedt D, Gerondopoulos A, Barr F, Piehler J, Engelbrecht-Vandré S, Ungermann C (2014) The Mon1-Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin-fold-Rab interface and association with PI3P-positive membranes. J Cell Sci 127, 1043-51.


Guo Z, Johnston W, Kovtun O, Mureev S, Bröcker C, Ungermann C, Alexandrov K (2013) Subunit organization of in vitro reconstituted HOPS and CORVET multisubunit membrane tethering complexes. PLoS One 8, e81534

Cabrera M, Ungermann C  (2013). Guanine nucleotide exchange factors (GEFs) have a critical but not exclusive role in organelle localization of Rab GTPases. J Biol Chem 288, 28704–28712.

Guo Z, Johnston W, Kovtun O, Mureev S, Bröcker C, Ungermann C , and Alexandrov K (2013). Subunit Organisation of In Vitro Reconstituted HOPS and CORVET Multisubunit Membrane Tethering Complexes. PLoS ONE, 8, e81534.

Epp N, Ungermann C  (2013). The N-Terminal Domains of Vps3 and Vps8 Are Critical for Localization and Function of the CORVET Tethering Complex on Endosomes. PLoS ONE 8, e67307.

kleine Balderhaar H, Lachmann J, Yavavli E, Bröcker C, Lürick A, Ungermann C  (2013) The CORVET tethering complex promotes tethering and fusion of Rab5/Vps21-positive membranes. PNAS 110, 3823-8.

John Peter AT, Lachmann J, Rana M, Bunge M, Cabrera M*, Ungermann C* (2013) The evolutionarily conserved BLOC-1 complex controls endosomal maturation by recruiting the Rab5 GTPase activating protein Msb3. J Cell Biol 201, 97-111. (*co-corresponding)

Cabrera M, Arlt H, Epp N, Lachmann J, Griffith J, Perz A, Reggiori F, Ungermann C (2013) Functional separation of endosomal fusion factors and the CORVET tethering complex in endosomal biogenesis. J Biol Chem, 288, 5166-75.

Rieter E, Vinke F, Bakula D, Cebollero E, Ungermann C, Projkas-Cezanne T, Reggiori F (2013) Atg18 function in autophagy is regulated by specific sites within its -propeller. J Cell Sci 126, 593-604


Cabrera A, Herrmann S, Warszta D, Santos JM, John Peter AT, Kono M, Debrouver S, Jacobs T, Spielmann T, Ungermann C, Soldati-Favre D, and Gilberger TW (2012) Dissection of the minimal sequence requirements for rhoptry membrane targeting in the malaria parasite. Traffic 13, 1335-50.

Bonfils G, Jaquenoud M, Bontron S, Ostrowicz C, Ungermann C, and De Virgilio C (2012) Leucyl-tRNA synthetase controls TORC1 via the EGO complex. Mol Cell 46, 105-110.

Lachmann J, Barr FA, Ungermann C (2012) The Msb3/Gyp3 GAP controls the activity of the Rab GTPases Vps21 and Ypt7 at endosomes and vacuoles. Mol Biol Cell 23, 2516-26.

Bröcker C, Kuhlee A, Gatsogiannis C, kleine Balderhaar H, Hönscher C, Engelbrecht-Vandré S, Ungermann C*, and Raunser S* (2011) Molecular architecture of the HOPS tethering complex. PNAS 109, 1991-1996 (*co-corresponding)


Kama R, Kanneganti V, Ungermann C, and Gerst JE (2011) The yeast Batten disease orthologue Btn1 controls endosome-Golgi retrograde transport via SNARE assembly. J Cell Biol 195, 203-215.

Arlt H, Perz A, Ungermann C (2011) An overexpression screen in Saccharomyces cerevisiae identifies novel genes that affect endocytic protein trafficking. Traffic 12, 1592-1603.

Krämer L, Ungermann C (2011) HOPS drives vacuole fusion by binding the vacuole SNARE complex and the Vam7 PX domain via two distinct sites. Mol Biol Cell 22, 2601-2611.

Meringer CT, Rethmeier R, Auffarth K, Wilson J, Perz A, Barlowe C, Schmitt HD, and Ungermann C (2011) The Dsl1 tethering complex is a resident ER complex, which interacts with five snares - implications for fusion and fusion regulation. J Biol Chem 286, 25039-46.


Cabrera M, Langemeyer L, Mari M, Rethmeier R, Orban I, Perz A, Bröcker C, Griffith J, Klose D, Steinhoff HJ, Reggiori F, Engelbrecht-Vandré S*, Ungermann C* (2010) Phosphorylation of a membrane curvature–sensing motif switches function of the HOPS subunit Vps41 in membrane tethering. J Cell Biol 191, 845-859. (*co-corresponding)

kleine Balderhaar H, Arlt H, Ostrowicz CW, Bröcker C, Sündermann F, Brandt R, Babst M, Ungermann C (2010) The Rab GTPase Ypt7 is linked to retromer-mediated receptor recycling and fusion at the yeast late endosome. J Cell Sci 123, 4085-94.

Nordmann M, Cabrera M, Perz A, Bröcker C, Ostrowicz CW, Engelbrecht-Vandré S, Ungermann C (2010) The Mon1-Ccz1 complex is the GEF of the late endosomal Rab7 homolog Ypt7. Curr Biol 20, 1654-59.


Markgraf D, Peplowska K, Mari M, Griffith J, Reggiori F*, Ungermann C* (2009) Direct interaction of the CORVET subunit Vps8 and the Rab5 GTPase Vps21 tethers late endosomal compartments. Mol Biol Cell 20, 5276-5289. (*co-corresponding)

Hou H, John Peter AT, Meiringer C, Subramanian K, Ungermann C (2009) Sorting of palmitoylated proteins in a network of DHHC acyltransferases with overlapping specificity. Traffic 10, 1061-73.

Cabrera M, Ostrowicz CW, Mari M, LaGrassa T, Reggiori F, Ungermann C (2009). Vps41 phosphorylation and the Rab Ypt7 control the targeting of the HOPS complex to endosome-vacuole fusion sites. Mol Biol Cell 20, 1937-48.


Meiringer C, Auffarth K, Hou H, Ungermann C  (2008). Depalmitoylation of the SNARE Ykt6 prevents its entry into the multivesicular body pathway. Traffic 9, 1511-21.

Takeda K, Cabrera M, Rohde J, Bausch D, Jensen ON, Ungermann C (2008) The vacuolar V(1)/V(0)-ATPase is involved in the release of the HOPS subunit Vps41 from vacuoles vacuole fragmentation and fusion. FEBS Lett, 582, 1558-63.

Pylypenko O, Schönichen A, Ludwig D, Ungermann C, Goody RS, Rak A, Geyer M (2008), Farnesylation of the SNARE protein Ykt6 increases ist stability and helical folding. J Mol Biol 377, 1334-45.


Peplowska C, Markgraf DM, Ostrowicz CF, Bange G, Ungermann C (2007) The CORVET tethering complex interacts with the yeast Rab5 homolog Vps21 and is involved in endo-lysosomal biogenesis. Dev Cell 12, 739-750.


Hofmann M, Peplowska K, Rohde J, Poschner BC, Ungermann C, Langosch D (2006) Self-interaction of a SNARE transmembrane domain promotes hemifusion-to-fusion transition. J Mol Biol 346, 1048-1060.

Roy R, Peplowka K, Rohde J, Ungermann C, Langosch D (2006) Role of the Vam3p transmembrane segment in homodimerization and SNARE complex formation, Biochemistry 45, 7654-7660.

Subramanian K, Dietrich LE, Hou H, LaGrassa C, Meiringer C, Ungermann C (2006) Palmitoylation determines the function of Vac8 at the yeast vacuole. J Cell Sci 119, 2477-2485.

Meiringer CT, Ungermann C (2006) Probing protein palmitoylation at yeast vacuoles, Methods 40, 171-176.


Hou H, Subramanian K, LaGrassa TJ, Markgraf D, Dietrich LE, Decker N, Ungermann C   (2005) The DHHC protein Pfa3 affects vacuole-associated palmitoylation of the fusion factor Vac8. PNAS 102, 17366-17371.

Dietrich LE, LaGrassa TJ, Rohde J, Cristodero M, Meiringer CT, Ungermann C (2005), ATP-independent control of Vac8 palmitoylation by a SNARE sub-complex on yeast vacuoles. J Biol Chem 280, 15348-55.

Dietrich LE, Peplowska K, LaGrassa T, Rohde J, Ungermann C (2005) The SNARE Ykt6 is released from yeast vacuoles during an early stage of fusion. EMBO Rep 6, 245-250.

LaGrassa T, Ungermann C (2005) The vacuolar kinase Yck3 maintains organelle fragmentation by regulating the HOPS tethering complex. J Cell Biol 168, 401-414.

Peplowska K, Ungermann C (2005) Expanding dynamin: from fission to fusion. Nat Cell Biol 7, 103-104.


Faergeman N, Feddersen S, Christiansen JK, Larsen MK, Schneiter R, Ungermann C, Mutenda, K., Roepstorff, P., and Knudsen, J. (2004)  Acyl-CoA-binding protein, Acb1p, is required for normal vacuole function and ceramide synthesis in Saccharomyces cerevisiae. Biochem J 380, 907-918.

Dietrich LE, Gurezka R, Veit M, Ungermann C (2004) The SNARE Ykt6 mediates protein palmitoylation during an early stage of yeast vacuole fusion. EMBO J 23, 45-53.


Veit M, Dietrich LE, Ungermann C (2003) Biochemical characterization of the vacuolar palmitoyl acyltransferase. FEBS letters 540, 101-105.

Rohde J, Dietrich L, Langosch D, Ungermann C (2002) The transmembrane domain of Vam3 affects the composition of cis- and trans-SNARE complexes in homotypic vacuole fusion. J. Biol. Chem. 278, 1656-1662.


Boeddinghaus C, Merz AJ, Laage R, Ungermann C (2002) A cycle of Vam7p release from and PtdIns-3-P-dependent rebinding to the yeast vacuole is required for homotypic vacuole fusion. J Cell Biol 157, 79-89.


Laage R, Ungermann C (2001) The N-terminal domain of the t-SNARE Vam3p coordinates priming and docking in yeast vacuole fusion. Mol Biol Cell 12, 3375-3385.

Veit M, Laage R, Dietrich L, Wang L, Ungermann C (2001) Vac8p-release from the SNARE complex and its palmitoylation are coupled and essential for vacuole fusion. EMBO J 20, 3145-3155.

Takita Y, Engestrom L, Ungermann C, and Cunningham KW (2001) Inhibition of the Ca2+-ATPase Pmc1p by the v-SNARE protein Nyv1p. J Biol Chem 276, 6200-6206.


Ungermann C, Price A, Wickner W (2000) A new role for a SNARE protein as a regulator of the Ypt/Rab-dependent stage of docking. PNAS 97, 8889-8891.

Wang L, Ungermann C, and Wickner W (2000) The docking of primed vacuoles can be reversibly arrested  by excess Sec17p (a-SNAP). J Biol Chem 275, 22862-22867.

Price AE, Wickner W, Ungermann C (2000) Proteins needed for vesicle budding from the Golgi are also required for the docking step of homotypic vacuole fusion. J Cell Biol 148, 1223-1230.

Price AE, Seals D, Wickner W, Ungermann C (2000) The docking stage of yeast vacuole fusion requires the transfer of proteins from the cis-SNARE complex to a Rab/Ypt protein. J Cell Biol 148, 1231-38.


Ungermann C, Wickner W, Xu Z (1999) Vacuole acidification is required for trans-SNARE pairing, LMA1 release and homotypic fusion. PNAS 96, 11194-11199.

Ungermann C, Fischer von Mollard G, Jensen O, Stevens TH, Wickner W (1999) Three v-SNAREs and two t-SNAREs, present in a pentameric cis-SNARE complex on isolated vacuoles, are required for homotypic fusion. J Cell Biol 145, 1435-1442.


Ungermann C, Sato K, Wickner W (1998) Defining the roles of trans SNARE pairs. Nature 396, 543-548.

Ungermann C, Wickner W (1998). Vam7p, a vacuolar SNAP-25 homolog, is required for SNARE complex integrity and vacuole docking and fusion. EMBO J 17, 3269-3276.

Ungermann C, Nichols BN, Pelham HRB, Wickner W (1998). A vacuolar v-t-SNARE complex, the predominant form in vivo and on isolated organelles, is disassembled and activated for docking and fusion. J Cell Biol 140, 61-69.

Gaume B, Klaus C, Ungermann C, Guiard B, Neupert W, and Brunner M (1998) Unfolding of preproteins upon import into mitochondria. EMBO J 17, 6497-6507.


Nichols BN, Ungermann C, Pelham HRB, Wickner W, and Haas A (1997) Homotypic vacuolar fusion mediated by v-and t-SNAREs. Nature 387, 199-202.

Gieffers C, Korioth F,  Heimann P, Ungermann C, and Frey J (1997) Mitofilin is a transmembrane protein of the inner mitochondrial membrane expressed as two isoforms. Exp Cell Res, 232, 395-9.

1996 and before

Wheeler LJ, Ray NB, Ungermann C, Hendricks SP, Bernard MA, Hanson EA, and Mathews CK (1996). T4 Phage Gene 32 Protein as a Candidate Organizing Factor for the dNTP Synthetase Complex. J Biol Chem 271, 11156-11162.

Ungermann C, Guiard B, Neupert W, and Cyr DM (1996) The ∆ and Hsp70/MIM44 dependent Reaction Cycle in Driving Early Steps of Protein Translocation into Mitochondria. EMBO J 15, 735-744.

Ungermann C, Neupert W, Cyr DM (1994). The Role of Hsp70 in Conferring Unidirectionality on Protein Translocation into Mitochondria. Science 266, 1250-1253.

Mathews CK, Wheeler LJ, Ungermann C, Young JP, and Ray NB (1993). Enzyme Interactions Involving T4-phage Coded Thymidylate Synthase and Deoxyhydroxymethylase. Adv Med Exp Biol 338, 563-570.

b) Reviews:

González Montoro A, Ungermann C (2015) StARTing to understand membrane contact sites. Trends Cell Biol, in press

Kuhlee A, Raunser S, Ungermann C (2015) Functional homologies in vesicle tethering. Febs Letters, in press

Langemeyer L, Ungermann C (2015) BORC and BLOC-1: Shared subunits in trafficking complexes. Dev Cell 33, 121-122.

Ungermann C (2015) vCLAMPs – an intimate link between vacuoles and mitochondria. Curr Opin Cell Biol 25, 30-36.

Kümmel D, Ungermann C (2014) Principles of membrane tethering and fusion in endosome and lysosome biogenesis. Curr Opin Cell Biol 29, 61-66.

Gautreau A, Oguievetskaia K, Ungermann C (2014) Function and regulation of the endosomal fusion and fission machineries. Cold Spring Harb Perspect Biol 6, pii: a016832

Hönscher C, Ungermann C (2014) A close-up view of membrane contact sites between the endoplasmic reticulum and the endolysosomal system: From yeast to man. Crit Rev Biochem Mol Biol 49, 262-268.

Numrich J, Ungermann C (2014) Endocytic Rabs in membrane trafficking and signaling. Biol Chem 395, 327-33.

Holthuis J, Ungermann C (2013) Cellular Microcompartments constitute general suborganellar functional units in cells. Biol Chem 394, 151-161.

kleine Balderhaar HJ, Ungermann C (2013) CORVET and HOPS tethering complexes – coordinators of endosome and lysosome fusion. J Cell Sci 126, 1307-1316.

Reggiori F, Ungermann C (2012) A dimer to bridge early autophagosomal membranes. Cell 151, 1403-05.

Epp N, Rethmeier R, Krämer L, Ungermann C (2011) Membrane dynamics and fusion at late endosomes and vacuoles - Rab regulation, multisubunit tethering complexes and SNAREs. EJCB 90, 779-785.

Lachmann J, Ungermann C, and Engelbrecht-Vandré S (2011) Rab GTPases and tethering in the yeast endocytic pathway. Small GTPases, 2, 182-186.

Bröcker C, Engelbrecht-Vandré S, Ungermann C (2010) Multisubunit tethering complexes and their role in membrane fusion, Curr Biol 20, R943-952.

Cabrera M, Ungermann C (2010) Guiding endosomal maturation, Cell 141, 404-406.

Cabrera M, Ungermann C (2009), Purification and in vitro analysis of yeast vacuoles, Methods Enzymol 451,177-96.

Peplowska K, Cabrera M, Ungermann C (2008) UVRAG reveals its second nature. Nat Cell Biol 10, 759-61.

Ostrowicz CF, Meiringer CM, Ungermann C (2008) Yeast vacuole fusion: A model system for eukaryotic endomembrane dynamics. Autophagy 4, 1-15.

Langosch D, Hoffmann M, Ungermann C (2007) The role of transmembrane domains in membrane fusion. Cell Mol Life Sci 64, 850-864.

Markgraf DM, Peplowska K, Ungermann C (2007) Rab cascades and tethering factors in the endomembrane system. FEBS letters 581, 2125-2130.

Meiringer CT, Ungermann C (2006) Probing protein palmitoylation at yeast vacuoles. Methods 40, 171-176.

Ungermann C , Langosch D (2005) Functions of SNAREs in intracellular membrane fusion and lipid bilayer mixing. J Cell Sci 118, 3819-3828.

Peplowska K, Ungermann C (2005) Expanding dynamin: from fission to fusion. Nat Cell Biol 7, 103-104.

Rossi V, Banfield DK, Vacca M, Dietrich LE, Ungermann C, D’Esposito M, Galli T, and Filippini F (2004) Longins and their longin domain: regulated SNAREs and multifunctional SNARE regulators. Trends Biochem Sci 29, 682-688.

Dietrich LE, Ungermann C (2004) On the mechanism of protein palmitoylation. EMBO Rep 5, 1053-1057.

Dietrich L, Boeddinghaus C, LaGrassa T, Ungermann C (2003) Control of eukaryotic membrane fusion by the N-terminal domains of SNARE proteins. BBA rev membranes 1641, 111-119.

Ungermann C, Neupert W, Cyr DM (1995) Regulation of Protein Transport through Mitochondrial Membranes.  Journal of NIH Research 6, 7, 60.

Cyr DM, Ungermann C, and Neupert, W (1995) Analysis of Mitochondrial Protein Import with Translocation Intermediates. Meth Enz, 260, 241-252.

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