{"id":673,"date":"2020-01-25T16:27:25","date_gmt":"2020-01-25T15:27:25","guid":{"rendered":"http:\/\/sagoebel.de\/UngermannLab\/Version_B\/?p=673"},"modified":"2020-08-25T17:25:58","modified_gmt":"2020-08-25T15:25:58","slug":"all-about-the-lysosome","status":"publish","type":"post","link":"https:\/\/www.biochemie.uni-osnabrueck.de\/?p=673","title":{"rendered":"All about the lysosome"},"content":{"rendered":"\n
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The lysosome<\/h2>\n\n\n\n
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– is the most exciting organelle of the eukaryotic cell. It is not just a bag of proteases that degrades lots of proteins and organelles, but is THE major recycling facility of the cell – everything that arrives is chopped into pieces and the monomers (amino acids, carbohydrates, lipids) are reused to build new proteins and organelles.<\/p>\n\n\n\n

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Research<\/div>
Endosome Maturation<\/div><\/div>

Endosomes are organelles that are localized at the branch point between plasma membrane and the vacuole, where membrane proteins are sorted into intraluminal vesicles or other proteins are removed for recycling. […]<\/p>\n<\/div><\/div><\/div>

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Autophagosome maturation<\/div>
Autophagosome maturation<\/div><\/div>

If cells starve, the use part of their cytosol and organelles and digest them \u2013 an essential process for survival of yeast and humans. This requires the ATG machinery to make an autophagosome to collect portions of the cell and digest them in the lysosome (Nobel prize to Yoshinori Ohsumi [\u2026]<\/p>\n<\/div><\/div><\/div>

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Tethering complexes<\/div>
Tethering complexes<\/div><\/div>

Tethering complexes are required to bring two membranes into proximity before they fuse. We study the HOPS and CORVET complexes, two large hexamers, which are essential for membrane fusion at the endosome and vacuole. [\u2026]<\/p>\n<\/div><\/div><\/div>

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Vacuole membrane homeostasis<\/div>
Vacuole membrane homeostasis<\/div><\/div>

How do cells measure the size of their organelles? Vacuoles are pretty large, yet also need to keep a certain size. Vacuoles form by fusing with endosomes and other vesicles. We favor the idea that the ratio of two lipids at endosomes and vacuole determine organelle size and function [\u2026]<\/p>\n<\/div><\/div><\/div>

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Vacuole contact sites<\/div>
Vacuole contact sites<\/div><\/div>

A long time ago, we thought that all organelles live their life without touching each other\u2026.well, this view has entirely changed. It seems that every organelle contacts one or many others, yet the function of these contacts is largely not known [\u2026]<\/p>\n<\/div><\/div><\/div>

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We use in vivo<\/em> and in vitro<\/em> approaches to understand the role of lysosomes in autophagy, endocytosis or growth, and use cellular models like the baker’s yeast or the fruit fly Drosophila to understand its physiology. <\/p>\n\n\n\n

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The lysosome – is the most exciting organelle of the eukaryotic cell. It is not just a bag of proteases that degrades lots of proteins and organelles, but is THE major recycling facility of the cell – everything that arrives is chopped into pieces and the monomers (amino acids, carbohydrates, lipids) are reused to build new…<\/p>\n","protected":false},"author":10,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-673","post","type-post","status-publish","format-standard","hentry","category-allgemein"],"_links":{"self":[{"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=\/wp\/v2\/posts\/673","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=673"}],"version-history":[{"count":49,"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=\/wp\/v2\/posts\/673\/revisions"}],"predecessor-version":[{"id":1645,"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=\/wp\/v2\/posts\/673\/revisions\/1645"}],"wp:attachment":[{"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=673"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=673"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=673"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}