{"id":953,"date":"2020-01-30T12:01:30","date_gmt":"2020-01-30T11:01:30","guid":{"rendered":"http:\/\/sagoebel.de\/UngermannLab\/Version_B\/?p=953"},"modified":"2020-05-08T10:25:04","modified_gmt":"2020-05-08T08:25:04","slug":"autophagosome-maturation","status":"publish","type":"post","link":"https:\/\/www.biochemie.uni-osnabrueck.de\/?p=953","title":{"rendered":"Autophagosome maturation"},"content":{"rendered":"\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"has-text-align-center wp-block-heading\">   Autophagosome maturation  <\/h2>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"664\" height=\"205\" src=\"https:\/\/www.biochemie.uni-osnabrueck.de\/wp-content\/uploads\/2019\/11\/Screen-Shot-2018-10-16-at-13.09.23-.jpg\" alt=\"\" class=\"wp-image-637\" srcset=\"https:\/\/www.biochemie.uni-osnabrueck.de\/wp-content\/uploads\/2019\/11\/Screen-Shot-2018-10-16-at-13.09.23-.jpg 664w, https:\/\/www.biochemie.uni-osnabrueck.de\/wp-content\/uploads\/2019\/11\/Screen-Shot-2018-10-16-at-13.09.23--300x93.jpg 300w, https:\/\/www.biochemie.uni-osnabrueck.de\/wp-content\/uploads\/2019\/11\/Screen-Shot-2018-10-16-at-13.09.23--150x46.jpg 150w\" sizes=\"auto, (max-width: 664px) 100vw, 664px\" \/><\/figure><\/div>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"sauron_divider\">\n            <span class=\"div_left\"><\/span>\n    <span class=\"div_middle\">\n      <i class=\"fa fa-stop\"><\/i>\n    <\/span>\n            <span class=\"div_right\"><\/span>\n          <\/div>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>If cells starve, they use part of their cytosol and organelles and digest them &#8211; an essential process for survival of yeast and humans. This requires the ATG machinery to make an autophagosome (Nobel prize to Yoshinori Ohsumi in 2016). We study the machinery that is responsible for autophagosome biogenesis and maturation. <\/p>\n\n\n\n<p>In the picture above, we analyzed a yeast mutant with a defect in fusion of autophagosomes with vacuoles (see Gao et al., elife 2018). At low temperature, an autophagy cargo (Atg8) arrives in the vacuole lumen. If we shift the cells to high temperature, cells still make autophagosomes (green circles), but they cannot fuse. Our group is analyzing, how the fusion machinery is recruited to and regulated at the autophagosome.<\/p>\n\n\n\n<p><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Autophagosome maturation If cells starve, they use part of their cytosol and organelles and digest them &#8211; an essential process for survival of yeast and humans. This requires the ATG machinery to make an autophagosome (Nobel prize to Yoshinori Ohsumi in 2016). We study the machinery that is responsible for autophagosome biogenesis and maturation. In&#8230;<\/p>\n","protected":false},"author":10,"featured_media":187,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-953","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-allgemein"],"_links":{"self":[{"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=\/wp\/v2\/posts\/953","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=953"}],"version-history":[{"count":8,"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=\/wp\/v2\/posts\/953\/revisions"}],"predecessor-version":[{"id":1228,"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=\/wp\/v2\/posts\/953\/revisions\/1228"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=\/wp\/v2\/media\/187"}],"wp:attachment":[{"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=953"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=953"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=953"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}