{"id":955,"date":"2020-01-30T12:03:03","date_gmt":"2020-01-30T11:03:03","guid":{"rendered":"http:\/\/sagoebel.de\/UngermannLab\/Version_B\/?p=955"},"modified":"2022-11-20T11:40:14","modified_gmt":"2022-11-20T10:40:14","slug":"tethering-complexes","status":"publish","type":"post","link":"https:\/\/www.biochemie.uni-osnabrueck.de\/?p=955","title":{"rendered":"Tethering complexes"},"content":{"rendered":"\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"has-text-align-center wp-block-heading\">    Tethering complexes   <\/h2>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"404\" src=\"https:\/\/www.biochemie.uni-osnabrueck.de\/wp-content\/uploads\/2022\/11\/Screenshot-2022-11-20-at-11.33.28-1024x404.png\" alt=\"\" class=\"wp-image-1934\" srcset=\"https:\/\/www.biochemie.uni-osnabrueck.de\/wp-content\/uploads\/2022\/11\/Screenshot-2022-11-20-at-11.33.28-1024x404.png 1024w, https:\/\/www.biochemie.uni-osnabrueck.de\/wp-content\/uploads\/2022\/11\/Screenshot-2022-11-20-at-11.33.28-300x118.png 300w, https:\/\/www.biochemie.uni-osnabrueck.de\/wp-content\/uploads\/2022\/11\/Screenshot-2022-11-20-at-11.33.28-768x303.png 768w, https:\/\/www.biochemie.uni-osnabrueck.de\/wp-content\/uploads\/2022\/11\/Screenshot-2022-11-20-at-11.33.28-1536x606.png 1536w, https:\/\/www.biochemie.uni-osnabrueck.de\/wp-content\/uploads\/2022\/11\/Screenshot-2022-11-20-at-11.33.28-2048x808.png 2048w, https:\/\/www.biochemie.uni-osnabrueck.de\/wp-content\/uploads\/2022\/11\/Screenshot-2022-11-20-at-11.33.28-150x59.png 150w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"sauron_divider\">\n            <span class=\"div_left\"><\/span>\n    <span class=\"div_middle\">\n      <i class=\"fa fa-stop\"><\/i>\n    <\/span>\n            <span class=\"div_right\"><\/span>\n          <\/div>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>Membrane fusion occurs at all cellular membranes. It is required for our thinking to release neurotransmitters and to release hormones from cells. This is not a trivial process as membranes need help to fuse with each other. <\/p>\n\n\n\n<p>Tethering complexes are required to bring two membranes into proximity before they fuse. They form both bridges between membranes and assist in the fusion process by binding membrane-anchored SNAREs (the grey bars in the model). <\/p>\n\n\n\n<p>We study the HOPS and CORVET complexes, two large hexamers, which are essential for membrane fusion at the endosome and vacuole &#8211; both in yeast and within human cells.  <\/p>\n\n\n\n<p>To understand their function, we purify both complexes and use reconstituted membrane tethering and fusion. In addition, we cooperate with Arne M\u00f6ller&#8217;s group in Osnabr\u00fcck &#8211; right next door(!) &#8211; and recently solved the structure of HOPS (see Shvarev, Schoppe, K\u00f6nig et al., elife 2022). More to come.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Tethering complexes Membrane fusion occurs at all cellular membranes. It is required for our thinking to release neurotransmitters and to release hormones from cells. This is not a trivial process as membranes need help to fuse with each other. Tethering complexes are required to bring two membranes into proximity before they fuse. They form both&#8230;<\/p>\n","protected":false},"author":10,"featured_media":187,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-955","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-allgemein"],"_links":{"self":[{"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=\/wp\/v2\/posts\/955","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=955"}],"version-history":[{"count":6,"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=\/wp\/v2\/posts\/955\/revisions"}],"predecessor-version":[{"id":1940,"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=\/wp\/v2\/posts\/955\/revisions\/1940"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=\/wp\/v2\/media\/187"}],"wp:attachment":[{"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=955"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=955"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=955"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}