{"id":960,"date":"2020-01-30T12:05:57","date_gmt":"2020-01-30T11:05:57","guid":{"rendered":"http:\/\/sagoebel.de\/UngermannLab\/Version_B\/?p=960"},"modified":"2023-01-06T13:05:56","modified_gmt":"2023-01-06T12:05:56","slug":"vacuole-contact-sites","status":"publish","type":"post","link":"https:\/\/www.biochemie.uni-osnabrueck.de\/?p=960","title":{"rendered":"Vacuole contact sites"},"content":{"rendered":"\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"has-text-align-center wp-block-heading\"> Vacuole contact sites <\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"684\" height=\"286\" src=\"https:\/\/www.biochemie.uni-osnabrueck.de\/wp-content\/uploads\/2019\/11\/Screen-Shot-2018-10-16-at-13.47.07-.jpg\" alt=\"\" class=\"wp-image-644\" srcset=\"https:\/\/www.biochemie.uni-osnabrueck.de\/wp-content\/uploads\/2019\/11\/Screen-Shot-2018-10-16-at-13.47.07-.jpg 684w, https:\/\/www.biochemie.uni-osnabrueck.de\/wp-content\/uploads\/2019\/11\/Screen-Shot-2018-10-16-at-13.47.07--300x125.jpg 300w, https:\/\/www.biochemie.uni-osnabrueck.de\/wp-content\/uploads\/2019\/11\/Screen-Shot-2018-10-16-at-13.47.07--150x63.jpg 150w\" sizes=\"auto, (max-width: 684px) 100vw, 684px\" \/><\/figure><\/div>\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"sauron_divider\">\n            <span class=\"div_left\"><\/span>\n    <span class=\"div_middle\">\n      <i class=\"fa fa-stop\"><\/i>\n    <\/span>\n            <span class=\"div_right\"><\/span>\n          <\/div>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>A long time ago, we thought that all organelles live their life without touching each other&#8230;.well, this view has entirely changed. It seems that every organelle contacts one or many others, yet the function is largely unknown. <\/p>\n\n\n\n<p>The above picture is an example of something unexpected &#8211; contact site between vacuoles and mitochondria caused by overexpression of the HOPS protein Vps39 (H\u00f6nscher et al., 2014; Gonzalez Montoro et al., 2018). These vCLAMP structures and many other contacts involved in lipid transport are a focus of <a href=\"https:\/\/www.biologie.uni-osnabrueck.de\/forschung\/arbeitsgruppen\/zellulaere_kommunikation\/dr_ayelen_gonzalez_montoro.html\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-cyan-blue-color\">Ayel\u00e9n Gonzalez Montoro&#8217;s group<\/mark><\/strong><\/a>. <\/p>\n\n\n\n<p>We rather study <strong>contact sites between vacuoles and endosomes or autophagosomes<\/strong>. Many of these sites will result eventually in membrane fusion of these organelles with the vacuole of these structures with the vacuole. We like to understand, how they are regulated to remain stable for a while, which proteins are modified, how their modification changes their function and which kinases (or other regulatory enzymes) detect these signals. Much of this occurs in the context of other projects (see <strong>endosomal maturation, autophagosome maturation<\/strong> projects). But you never know, where we get here&#8230;.   <br>   <\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Vacuole contact sites A long time ago, we thought that all organelles live their life without touching each other&#8230;.well, this view has entirely changed. It seems that every organelle contacts one or many others, yet the function is largely unknown. The above picture is an example of something unexpected &#8211; contact site between vacuoles and&#8230;<\/p>\n","protected":false},"author":10,"featured_media":187,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-960","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-allgemein"],"_links":{"self":[{"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=\/wp\/v2\/posts\/960","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=960"}],"version-history":[{"count":10,"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=\/wp\/v2\/posts\/960\/revisions"}],"predecessor-version":[{"id":2038,"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=\/wp\/v2\/posts\/960\/revisions\/2038"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=\/wp\/v2\/media\/187"}],"wp:attachment":[{"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=960"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=960"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.biochemie.uni-osnabrueck.de\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=960"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}